It took a while but I found the post by Brian- here are some snippets which I feel define the diiference between a layout and a design
Our expereince with merchants has shown that a Actinic theme may help a merchant start a site and get it live but you really need a professional design to give your visiters the comfort level to know your serious as an online merchant and a true professional organization. Location is number one in my book but right after location is "making a good first impression". You may have 10 seconds to impress your visitor.
give it a more professional feeling by incorporating some images in the header and softening the look by actually embedding a design into the themes.
but your gonna need a good site design to really make an impact in sales. Here is a site we built that sells greek stuff, http://greektownimports.com. This site use to use a generic template. After the redeployment their sales have more then tripled. Quality design is pleasing on the eye, functional for a the user to navigate and it build confidence in your potential customer.
wrap that content with an excellent web design and you will have a winner.
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